Alright, I haven't seen a thread for this, so I dunno if it's just me or Dark Injection, but I've never had this happen before using Dark Injection.
When in any creator, the mouse/camera doesn't want to work or do anything when in a certain area, which usually tends to be around the outside of the normal area. I don't know if there's a reason for this, but it seems to only not work when the mouse is over where the normal spore GUI stuff would be for the creation's skills/attributes. I use the full Darkspore UI, so I believe that the issue lies only with that, but I'm unsure.
I know it says only one thing, but there's also a weird thing when you view creations from the sporepedia, where the GUI is the same as normal Spore but the buttons to edit/share/whatever else... aren't.
Neither of these are really that bad of a setback, just little oddities that I noticed and decided to mention.